Linked Life Data

7525213

Source:http://linkedlifedata.com/resource/pubmed/id/7525213

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-12-27
pubmed:abstractText
UDPG-glucuronyltransferase (GT) activities have been determined in the hepatic microsomes of fish species recommended by OECD for some (eco)toxicological tests. Due to the heterogeneity of this enzyme family, different chemicals were used as substrate: 4-nitrophenol (4NP), 4 methylumbelliferone (4MU), and 2- and 4-hydroxybiphenyl (2OHB and 4OHB). The 4NP-GT and 2OHB-GT activities of hepatic microsomes from all the species were linearly dependent on the substrate concentration (tested concentrations up to 2 and 0.5 mM, respectively). 4OHB-GT and 4MU-GT demonstrated different degrees of saturation in the range of substrate concentrations 0-0.5 mM and 0-0.3 mM, respectively. Specific activities ranged among the species usually within a factor of about 3. The highest ratios (up to 10) were occasionally found for 4MU-GT (between trout and golden orfe) and 2OHB-GT (between guppy and carp, zebra fish, or trout). These results confirm that GT activities in fish are much lower than in mammals.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0147-6513
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
172-80
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Xenobiotic-metabolizing enzyme systems in test fish. V. Comparative studies of liver microsomal glucuronyltransferases.
pubmed:affiliation
Biochemical Toxicology Unit, Istituto Superiore di Sanità, Rome, Italy.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't