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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-12-19
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pubmed:abstractText |
The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0300-0664
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
337-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:7525120-Adolescent,
pubmed-meshheading:7525120-Adult,
pubmed-meshheading:7525120-Blood Glucose,
pubmed-meshheading:7525120-Carrier Proteins,
pubmed-meshheading:7525120-Drug Administration Schedule,
pubmed-meshheading:7525120-Fatty Acids, Nonesterified,
pubmed-meshheading:7525120-Female,
pubmed-meshheading:7525120-Growth Disorders,
pubmed-meshheading:7525120-Growth Hormone,
pubmed-meshheading:7525120-Humans,
pubmed-meshheading:7525120-Injections, Subcutaneous,
pubmed-meshheading:7525120-Insulin,
pubmed-meshheading:7525120-Insulin-Like Growth Factor Binding Proteins,
pubmed-meshheading:7525120-Insulin-Like Growth Factor I,
pubmed-meshheading:7525120-Male,
pubmed-meshheading:7525120-Somatomedins
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pubmed:year |
1994
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pubmed:articleTitle |
Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.
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pubmed:affiliation |
Medical Department M (Diabetes and Endocrinology), Aarhus Kommunehospital, Denmark.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
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