Linked Life Data

7523460

Source:http://linkedlifedata.com/resource/pubmed/id/7523460

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-10-27
pubmed:abstractText
Electric fish generate an electric field, which they sense with cutaneous electroreceptors. Electroreceptors project topographically onto the medullary electrosensory lateral line lobe (ELL). The ELL of gymnotiform electric fish is divided into four segments specialized to detect different aspects of the electrosensory input; it is also laminated with separate laminae devoted to electroreceptive input, interneurons, projection neurons, and feedback input. We have utilized antisera to glutamic acid decarboxylase (GAD) and gamma-aminobutyric acid (GABA) to map the distribution of GABAergic cells and fibers in the ELL of the gymnotiform fish, Apteronotus leptorhynchus. Six types of GABAergic interneurons are found in ELL: Type 2 granular cells (granular layer) project to pyramidal cells; polymorphic cells (pyramidal cell layer) project to the non-GABAergic type 1 granular cells; ovoid cells (deep neuropil layer) project bilaterally upon basilar dendrites of pyramidal cells; multipolar cells (deep neuropil layer) project bilaterally, probably to dendrites and neurons within the deep neuropil layer; and neurons of the ventral molecular layer and stellate cells (molecular layer) project to apical dendrites of pyramidal cells. GABAergic bipolar cells in the nucleus praeminentialis, a rhombencephalic structure devoted to feedback in the electrosensory system, project in relatively diffuse fashion to pyramidal cells. We hypothesize that the various GABAergic circuits of the ELL can be correlated with specific functions: type 2 granular cells with adaptation, size of receptive field center, and gain; polymorphic cells and type 1 granular cells with regulation of surround inhibition; ovoid cells with common mode rejection; and neurons of the ventral molecular layer with adaptive gain control. The feedback GABAergic input from bipolar cells of n. praeminentialis to pyramidal cells may be part of a searchlight mechanism similar to the one postulated for thalamocortical systems.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-9967
pubmed:author
pubmed:issnType
Print
pubmed:day
8
pubmed:volume
345
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
224-52
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7523460-Animals, pubmed-meshheading:7523460-Dendrites, pubmed-meshheading:7523460-Electric Fish, pubmed-meshheading:7523460-Glutamate Decarboxylase, pubmed-meshheading:7523460-Horseradish Peroxidase, pubmed-meshheading:7523460-Immunohistochemistry, pubmed-meshheading:7523460-Interneurons, pubmed-meshheading:7523460-Mechanoreceptors, pubmed-meshheading:7523460-Neural Pathways, pubmed-meshheading:7523460-Neurons, Afferent, pubmed-meshheading:7523460-Pyramidal Cells, pubmed-meshheading:7523460-Sense Organs, pubmed-meshheading:7523460-Sodium Channels, pubmed-meshheading:7523460-Tissue Embedding, pubmed-meshheading:7523460-Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate, pubmed-meshheading:7523460-Wheat Germ Agglutinins, pubmed-meshheading:7523460-gamma-Aminobutyric Acid
pubmed:year
1994
pubmed:articleTitle
Correlating gamma-aminobutyric acidergic circuits and sensory function in the electrosensory lateral line lobe of a gymnotiform fish.
pubmed:affiliation
Department of Anatomy and Neurobiology, Faculty of Medicine, University of Ottawa, Ontario, Canada.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't