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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0021745,
umls-concept:C0079189,
umls-concept:C0521115,
umls-concept:C0871261,
umls-concept:C1291803,
umls-concept:C1414406,
umls-concept:C1423842,
umls-concept:C1514623,
umls-concept:C1516451,
umls-concept:C1533691,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1819447,
umls-concept:C1819457,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
2
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pubmed:dateCreated |
1994-11-8
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pubmed:abstractText |
Disease progression in HIV-1 infection is reported to be associated with a gradual shift in CD4+ T cell function from a Th type 1 to a Th type 2 of response, but the underlying mechanism remains unclear. In this study, the effect of HIV-1 envelope glycoprotein gp160 on secretion of cytokines IFN-gamma/IL-2 (Th1 type) and IL-4 (Th2 type) was analyzed using freshly isolated unfractioned peripheral blood mononuclear cells (PBMC), CD4+ T cell lines, and PBMC depleted of CD8+ cells (CD8- PBMC) as target cells. Pretreatment of these cells with HIV gp160 significantly reduced PHA-induced secretion of IFN-gamma and IL-2 but augmented IL-4 production. This effect of gp160 was not observed when the target cells consisted of PBMC depleted of either CD4+ cells (CD4- PBMC) or of CD2+ cells (CD2- PBMC). Pretreatment of gp160 with soluble CD4-immunoglobulin chimeric molecules abrogated the observed effects of gp160, suggesting that CD4-gp120 interaction is required for modification of the cytokine secretion profile. Our results suggest that exposure of CD4+ T cells to HIV-1 envelope proteins may modify the responses evoked by additional stimuli in favor of a Th2-type dominant response.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Gene Products, env,
http://linkedlifedata.com/resource/pubmed/chemical/HIV Envelope Protein gp160,
http://linkedlifedata.com/resource/pubmed/chemical/Interferons,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Precursors
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0090-1229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
73
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
245-51
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7523014-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7523014-Cytokines,
pubmed-meshheading:7523014-Gene Products, env,
pubmed-meshheading:7523014-HIV Envelope Protein gp160,
pubmed-meshheading:7523014-Humans,
pubmed-meshheading:7523014-Interferons,
pubmed-meshheading:7523014-Interleukin-2,
pubmed-meshheading:7523014-Interleukin-4,
pubmed-meshheading:7523014-Protein Precursors,
pubmed-meshheading:7523014-Th1 Cells,
pubmed-meshheading:7523014-Th2 Cells
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pubmed:year |
1994
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pubmed:articleTitle |
HIV-1 gp160 as a modifier of Th1 and Th2 cytokine response: gp160 suppresses interferon-gamma and interleukin-2 production concomitantly with enhanced interleukin-4 production in vitro.
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pubmed:affiliation |
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York, New York 11030.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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