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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1978-4-17
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pubmed:abstractText |
A rational comparison of different serum concentrations of alpha1-fetoprotein (S-AFP) in the diagnosis of hepatoma must be made. We took data on the sensitivity and specificity of different diagnostic S-AFP concentrations from the literature and evaluated them statistically and by Bayesian analysis. In our patients (hepatoma prevalence 0.028) a sensitive diagnostic concentration (30-50 ng/ml) will misdiagnose hepatoma so often that a positive test will indicate hepatoma in only 10% of cases. A positive test at a specific diagnostic concentration (500 ng/ml) indicates hepatoma in 100% of cases and is preferable in terms of cost benefit. Although the lower concentration will diagnose a larger proportion of patients with hepatoma (74% compared with 59%) the 'costs' of excluding false positives are considerable (A$2545 per extra case with 2.5% of patients suffering significant morbidity). In western societies, where the prevalence of hepatoma is low, a higher, less sensitive but more specific diagnostic S-AFP concentration is appropriate.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-13111413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-14925381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4107670,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4108552,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4111613,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4114529,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4118727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4122309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4122743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4131842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4136060,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4140084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4195138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4264358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4358588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4365301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4374083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4551224,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-4742316,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-5029066,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-5530642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/75213-806804
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0021-9746
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
30
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1129-33
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1977
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pubmed:articleTitle |
Alpha1-fetoprotein in the diagnosis of hepatoma: statistical and cost benefit aspects.
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pubmed:publicationType |
Journal Article
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