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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-10-5
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pubmed:abstractText |
In HIV-infected adults prolonged monotherapy with zidovudine may be associated with the appearance of HIV strains with decreased zidovudine sensitivity, owing to specific mutations in the reverse transcriptase (RT) gene, and this has been suggested to be a reason for reduced zidovudine efficacy. This study was undertaken to determine the appearance of mutation at codon 215 of the RT gene in proviral DNA from PBMCs in HIV-infected children.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0889-2229
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
721-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:7521192-Base Sequence,
pubmed-meshheading:7521192-Child,
pubmed-meshheading:7521192-Child, Preschool,
pubmed-meshheading:7521192-DNA Probes,
pubmed-meshheading:7521192-Drug Resistance, Microbial,
pubmed-meshheading:7521192-HIV Infections,
pubmed-meshheading:7521192-HIV Reverse Transcriptase,
pubmed-meshheading:7521192-HIV-1,
pubmed-meshheading:7521192-Humans,
pubmed-meshheading:7521192-Infant,
pubmed-meshheading:7521192-Molecular Sequence Data,
pubmed-meshheading:7521192-Mutation,
pubmed-meshheading:7521192-Prospective Studies,
pubmed-meshheading:7521192-RNA-Directed DNA Polymerase,
pubmed-meshheading:7521192-Treatment Outcome,
pubmed-meshheading:7521192-Zidovudine
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pubmed:year |
1994
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pubmed:articleTitle |
HIV-1 reverse transcriptase codon 215 mutation and clinical outcome in children treated with zidovudine.
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pubmed:affiliation |
Pediatric Department (IV), University of Milan, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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