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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-9-29
|
| pubmed:abstractText |
A total of 71 patients with clinically localized prostatic cancer underwent preoperative biopsy of each seminal vesicle. Group 1 (67 patients) underwent 2 seminal vesicle biopsies before lymph node dissection and vesiculo-prostatectomy, while group 2 (4 patients) underwent seminal vesicle biopsy and lymph node dissection before radiation therapy. In group 1 there were 11 positive biopsies (16.5%) with a median prostate specific antigen (PSA) level of 24 ng./ml. (range 11 to 45). Of the biopsies 56 were normal, with a median PSA level of 11.8 (range 3.5 to 88, p < 0.008). Histological examination of the seminal vesicles on the prostatectomy specimen revealed 18 cases of seminal vesicle invasion (sensitivity 61%, specificity 100%, positive predictive value 100% and negative predictive value 87.5%). A positive biopsy was correlated with the mean tumor volume (10.3 cc with positive biopsies versus 4.9 cc with negative biopsies) and local invasion (positive margins in 36% versus 9%, respectively, and capsular perforation in 81% versus 25%, respectively). In group 2 the 4 seminal vesicle biopsies and lymph node dissections were positive. Overall (groups 1 and 2), positive seminal vesicle biopsies were predictive of lymph node involvement in 47% of the cases versus 7% when biopsies were negative (p > 0.001). The postoperative course was significantly different (local recurrence and metastases in 45% versus 9%, respectively, and median interval 8.8 months versus 18.3 months, respectively, p < 0.001). Seminal vesicle biopsy appears to have a satisfactory yield only in cases with a PSA level of greater than 10 ng./ml. A positive seminal vesicle biopsy confirms the presence of extraprostatic invasion of clinically localized cancer in a given patient. Seminal vesicle biopsy allows for better staging of prostatic cancer.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
0022-5347
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
152
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1152-6
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7520948-Biopsy,
pubmed-meshheading:7520948-Humans,
pubmed-meshheading:7520948-Lymphatic Metastasis,
pubmed-meshheading:7520948-Male,
pubmed-meshheading:7520948-Neoplasm Invasiveness,
pubmed-meshheading:7520948-Neoplasm Staging,
pubmed-meshheading:7520948-Predictive Value of Tests,
pubmed-meshheading:7520948-Preoperative Care,
pubmed-meshheading:7520948-Prostate-Specific Antigen,
pubmed-meshheading:7520948-Prostatectomy,
pubmed-meshheading:7520948-Prostatic Neoplasms,
pubmed-meshheading:7520948-Seminal Vesicles,
pubmed-meshheading:7520948-Sensitivity and Specificity
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Influence of preoperative positive seminal vesicle biopsy on the staging of prostatic cancer.
|
| pubmed:affiliation |
Department of Urology, Centre Medico-Chirurgical de la Porte de Choisy, Paris, France.
|
| pubmed:publicationType |
Journal Article
|