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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1994-9-23
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pubmed:abstractText |
The childhood-onset cerebral form of adrenoleukodystrophy has a devastating neurologic prognosis. Unfortunately, there is no early method of distinguishing it from the more benign forms of adrenoleukodystrophy, such as adrenomyeloneuropathy. To evaluate the manner in which this disease entity may be reflected in the cerebrospinal fluid, we studied a consecutive series of 19 patients, all with biochemically proved adrenoleukodystrophy. total protein, immunoglobulin production, cytokine levels, and cerebrospinal fluid pressure were measured. In this single sample of cerebrospinal fluid, a significant correlation existed between clinical stage of the illness and cerebrospinal fluid myelin basic protein. No correlation existed with total protein, cytokines, or measures of immunoglobulin production.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0887-8994
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-94
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7520699-Adolescent,
pubmed-meshheading:7520699-Adrenoleukodystrophy,
pubmed-meshheading:7520699-Cerebrospinal Fluid Pressure,
pubmed-meshheading:7520699-Cerebrospinal Fluid Proteins,
pubmed-meshheading:7520699-Child,
pubmed-meshheading:7520699-Child, Preschool,
pubmed-meshheading:7520699-Cytokines,
pubmed-meshheading:7520699-Diagnosis, Differential,
pubmed-meshheading:7520699-Female,
pubmed-meshheading:7520699-Humans,
pubmed-meshheading:7520699-Immunoglobulin G,
pubmed-meshheading:7520699-Male,
pubmed-meshheading:7520699-Myelin Basic Proteins,
pubmed-meshheading:7520699-Prognosis,
pubmed-meshheading:7520699-Severity of Illness Index
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pubmed:year |
1994
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pubmed:articleTitle |
CSF findings in adrenoleukodystrophy: correlation between measures of cytokines, IgG production, and disease severity.
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pubmed:affiliation |
Division of Pediatric Neurology, University of Minnesota Medical School, Minneapolis.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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