|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5176
|
|
pubmed:dateCreated |
1994-9-19
|
|
pubmed:abstractText |
Experimental autoimmune encephalomyelitis (EAE) is a cell-mediated autoimmune disease that serves as an animal model for multiple sclerosis. Oral administration of myelin basic protein (MBP) suppresses EAE by inducing peripheral tolerance. T cell clones were isolated from the mesenteric lymph nodes of SJL mice that had been orally tolerized to MBP. These clones were CD4+ and were structurally identical to T helper cell type 1 (TH1) encephalitogenic CD4+ clones in T cell receptor usage, major histocompatibility complex restriction, and epitope recognition. However, they produced transforming growth factor-beta with various amounts of interleukin-4 and interleukin-10 and suppressed EAE induced with either MBP or proteolipid protein. Thus, mucosally derived TH2-like clones induced by oral antigen can actively regulate immune responses in vivo and may represent a different subset of T cells.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
0036-8075
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
26
|
|
pubmed:volume |
265
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1237-40
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:7520605-Administration, Oral,
pubmed-meshheading:7520605-Amino Acid Sequence,
pubmed-meshheading:7520605-Animals,
pubmed-meshheading:7520605-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7520605-Clone Cells,
pubmed-meshheading:7520605-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:7520605-Epitopes,
pubmed-meshheading:7520605-Immune Tolerance,
pubmed-meshheading:7520605-Interleukin-10,
pubmed-meshheading:7520605-Interleukin-4,
pubmed-meshheading:7520605-Lymph Nodes,
pubmed-meshheading:7520605-Major Histocompatibility Complex,
pubmed-meshheading:7520605-Mesentery,
pubmed-meshheading:7520605-Mice,
pubmed-meshheading:7520605-Molecular Sequence Data,
pubmed-meshheading:7520605-Myelin Basic Proteins,
pubmed-meshheading:7520605-Myelin Proteins,
pubmed-meshheading:7520605-Myelin Proteolipid Protein,
pubmed-meshheading:7520605-Receptors, Antigen, T-Cell,
pubmed-meshheading:7520605-Transforming Growth Factor beta
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis.
|
|
pubmed:affiliation |
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
