Linked Life Data

7520505

Source:http://linkedlifedata.com/resource/pubmed/id/7520505

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-20
pubmed:abstractText
A symmetric dimer of a polypeptide in an organic solvent is shown to be a useful molecular system for observing the effects of crystal packing and solution dynamics on structure determination by X-ray crystallography and solution NMR methods. Organic solvents are not ideal models of a lipid environment, but they represent a better model environment than does water, in fact, for modeling some properties of the lipid environment, organic solvents work very well. In particular, it is a good model for assessing the influence of lipids on local polypeptide dynamics and conformational rearrangements. The solution NMR structure of gramicidin in the mixed solvent of benzene and ethanol is compared to the crystal structure formed from a benzene/ethanol azeotrope. High resolution structural characterization leads to unique correlations of disorder in the crystal to dynamics in solution. Furthermore, crystal packing effects lead to significant asymmetries in both the polypeptide backbone and in the side-chains.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2836
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
241
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Polypeptide conformational space. Dynamics by solution NMR disorder by X-ray crystallography.
pubmed:affiliation
Institute of Molecular Biophysics, Florida State University, Tallahassee 32306-3006.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.