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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-9-19
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pubmed:abstractText |
We have generated TCR transgenic mice (T/R+) specific for myelin basic protein (MBP) and crossed them to RAG-1-deficient mice to obtain mice (T/R-) that have T cells expressing the transgenic TCR but no other lymphocytes. Both T/R+ and T/R- mice carry, in the lymph nodes and spleen, large numbers of the potentially encephalitogenic CD4+ anti-MBP T cells. These cells respond to MBP in vitro but show no signs of activation in vivo. Nevertheless, approximately 14% of H-2u T/R+ and 100% of H-2u T/R- mice developed spontaneous experimental autoimmune encephalomyelitis (EAE) within 12 months. These data indicate that EAE can be mediated by CD4+ anti-MBP T cells in the absence of any other lymphocytes and that nontransgenic lymphocytes that are present in T/R+ but absent in T/R- mice have a protective effect. The data also suggest that spontaneous EAE may be triggered by an in situ activation of CD4+ anti-MBP cells in the nervous system.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
12
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
399-408
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7520367-Amino Acid Sequence,
pubmed-meshheading:7520367-Animals,
pubmed-meshheading:7520367-Autoimmune Diseases,
pubmed-meshheading:7520367-Central Nervous System,
pubmed-meshheading:7520367-Crosses, Genetic,
pubmed-meshheading:7520367-Encephalomyelitis,
pubmed-meshheading:7520367-Flow Cytometry,
pubmed-meshheading:7520367-Homeodomain Proteins,
pubmed-meshheading:7520367-Immunohistochemistry,
pubmed-meshheading:7520367-Lymphocyte Activation,
pubmed-meshheading:7520367-Lymphocytes,
pubmed-meshheading:7520367-Mice,
pubmed-meshheading:7520367-Mice, Transgenic,
pubmed-meshheading:7520367-Molecular Sequence Data,
pubmed-meshheading:7520367-Myelin Basic Proteins,
pubmed-meshheading:7520367-Proteins,
pubmed-meshheading:7520367-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:7520367-Spleen
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pubmed:year |
1994
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pubmed:articleTitle |
High incidence of spontaneous autoimmune encephalomyelitis in immunodeficient anti-myelin basic protein T cell receptor transgenic mice.
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pubmed:affiliation |
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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