Linked Life Data

7519790

Source:http://linkedlifedata.com/resource/pubmed/id/7519790

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-9-8
pubmed:abstractText
The sequential cascades in leukocyte adhesion and migration are important events in the development of inflammatory and immune responses in Behçet's disease. In an attempt to clarify the relation of active ocular lesions to inflammatory reactions covering entire body, we have detected LECAM-1, Mac-1 and CD44 expressed on the peripheral leukocytes in 24 Behçet patients and 15 healthy adults by flow cytometry. LECAM-1 and CD44 expression was dramatically decreased from the polymorphonuclear leukocytes (PMN) upon ocular attacks, whereas the changes in Mac-1 appeared not so striking. This tendency had continued into the recovery stage of ocular inflammation. T lymphocytes showed, on the other hand, no considerable variability in regard to the expression of cell surface LECAM-1, CD44 and also of Mac-1 even at the peak of active ocular inflammation. The results suggest that interaction between PMN and primed vascular endothelial cells might be apt to precede functional modifications of T lymphocytes, and it is also supposed that facilitation of activated PMN recruitment plays an essential role on ocular inflammation in Behçet's disease.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0300-9157
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
608-15
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
[Peripheral leukocyte adhesion molecules in patients of Behçet's disease associated with active ocular lesions].
pubmed:affiliation
Kanagawa Rehabilitation Institute.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't