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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
1994-8-31
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pubmed:databankReference |
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pubmed:abstractText |
We have isolated and characterized a rat delta-opioid receptor. The deduced amino acid sequence (372 aa) closely resembles the murine delta-opioid receptor, DOR-1. In fact, 97% of the amino acid residues are conserved between the two species, while 93% of the nucleic acid residues are identical. A 6 kb mRNA was detected in rat cortex using rat DOR-1 as a probe. When expressed in COS cells, the clone shows high-affinity opioid binding with selectivity for delta-opioids. The rat delta-opioid receptor cDNA clone will be a useful tool for studying the function of delta-opioid receptor in rats.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0360-4012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
714-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7519274-Amino Acid Sequence,
pubmed-meshheading:7519274-Animals,
pubmed-meshheading:7519274-Base Sequence,
pubmed-meshheading:7519274-Blotting, Northern,
pubmed-meshheading:7519274-Brain Chemistry,
pubmed-meshheading:7519274-Cells, Cultured,
pubmed-meshheading:7519274-Cloning, Molecular,
pubmed-meshheading:7519274-DNA, Complementary,
pubmed-meshheading:7519274-DNA Probes,
pubmed-meshheading:7519274-Diprenorphine,
pubmed-meshheading:7519274-Gene Library,
pubmed-meshheading:7519274-Molecular Sequence Data,
pubmed-meshheading:7519274-Olfactory Bulb,
pubmed-meshheading:7519274-RNA,
pubmed-meshheading:7519274-Rats,
pubmed-meshheading:7519274-Rats, Sprague-Dawley,
pubmed-meshheading:7519274-Receptors, Opioid, delta,
pubmed-meshheading:7519274-Transfection
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pubmed:year |
1994
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pubmed:articleTitle |
Molecular cloning and expression of a delta-opioid receptor from rat brain.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, Medical College of Virginia, Richmond.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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