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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1994-9-1
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pubmed:abstractText |
To investigate the relaxatory effect and mode of action of substance P in the human umbilical artery, ring segments of the artery were suspended in organ baths to record the circular motor activity. Substance P induced a significant relaxation in segments with intact endothelium pre-contracted by potassium or 5-hydroxytryptamine. Segments devoid of their endothelium failed to relax when challenged with substance P. The relaxation induced by substance P was inhibited by the cyclo-oxygenase antagonist indomethacin, while the nitric oxide-synthetase inhibitor L-NG-monomethyl-arginine was without effect. These findings suggest that the relaxatory effect of substance P in the human umbilical artery is dependent on an intact endothelium. In contrast to the case in most other vessels, the relaxation is not mediated via the release of endothelium-derived relaxing factor, but seems to be dependent on prostanoid synthesis.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
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pubmed:issn |
0268-1161
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
733-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7519198-Endothelium, Vascular,
pubmed-meshheading:7519198-Humans,
pubmed-meshheading:7519198-Indomethacin,
pubmed-meshheading:7519198-Muscle Contraction,
pubmed-meshheading:7519198-Potassium,
pubmed-meshheading:7519198-Prostaglandins,
pubmed-meshheading:7519198-Substance P,
pubmed-meshheading:7519198-Umbilical Arteries,
pubmed-meshheading:7519198-Vasodilation
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pubmed:year |
1994
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pubmed:articleTitle |
Endothelium-dependent relaxation to substance P in human umbilical artery is mediated via prostanoid synthesis.
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pubmed:affiliation |
Department of Obstetrics and Gynaecology at Malmö, University of Lund, General Hospital, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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