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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1994-8-24
|
| pubmed:abstractText |
Premature rupture of membranes (PROM) is sometimes difficult to diagnose. This report proposes the use of alpha-feto-protein (AFP) values in vaginal secretions for diagnostic tests. Our investigation took place in two separate phases. The first phase validated the AFP test using an immuno-enzymatic assay method and determined a threshold value from a sample of 167 female patients (Group 1: 133 patients with an extremely low probability of PROM, and Group 2: 54 patients with confirmed PROM). In the second phase the test was applied to a sample of 145 female patients (Group 3) with suspected, but unconfirmed, PROM. Results from alpha-feto-protein (AFP) evaluation were compared with data obtained from clinical, echographic and other tests. The positive/negative threshold adopted was an AFP concentration of 30 micrograms/l. For the two first groups, 1 and 2, sensitivity and specificity was in the 98% to 99% confidence level. For Group 3, sensitivity and specificity results at the 30 micrograms/l threshold value were 94.5% and 95.4% respectively. Quantitative measurement of AFP determined by immuno-enzymatic assay of vaginal secretions with a threshold of 30 micrograms/l is a reliable, simple and rapid diagnostic test. Results obtained are significantly better than the measurement of pH, the determination of prolactin, and more practical than diamino-oxidase (DAO) assays.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0001-6349
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
73
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
456-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7518992-Female,
pubmed-meshheading:7518992-Fetal Membranes, Premature Rupture,
pubmed-meshheading:7518992-Humans,
pubmed-meshheading:7518992-Immunoenzyme Techniques,
pubmed-meshheading:7518992-Pregnancy,
pubmed-meshheading:7518992-Sensitivity and Specificity,
pubmed-meshheading:7518992-Vagina,
pubmed-meshheading:7518992-Vaginal Smears,
pubmed-meshheading:7518992-alpha-Fetoproteins
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Diagnosis of premature rupture of the membranes by the identification of alpha-feto-protein in vaginal secretions.
|
| pubmed:affiliation |
Gynecological and Obstetrics Service, Hopital de la Croix Rousse, Lyon, France.
|
| pubmed:publicationType |
Journal Article
|