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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1994-8-17
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pubmed:abstractText |
We have proved that iNOS is regulated by induction of transcription. The induction of iNOS mRNA requires synthesis of an intermediary protein(s) and probably involves action of a protein kinase or kinases. We have cloned and sequenced a 1.7-kilobase pair fragment from the 5'-flanking region of the iNOS gene and proved that this region contains a promoter which confers inducibility of iNOS by LPS and IFN-gamma.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0066-9458
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
106
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pubmed:geneSymbol |
iNOS
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1-12
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:7518621-Amino Acid Oxidoreductases,
pubmed-meshheading:7518621-Animals,
pubmed-meshheading:7518621-Base Sequence,
pubmed-meshheading:7518621-Calcium,
pubmed-meshheading:7518621-Cloning, Molecular,
pubmed-meshheading:7518621-Cycloheximide,
pubmed-meshheading:7518621-DNA,
pubmed-meshheading:7518621-Enzyme Induction,
pubmed-meshheading:7518621-Interferon-gamma,
pubmed-meshheading:7518621-Lipopolysaccharides,
pubmed-meshheading:7518621-Macrophages,
pubmed-meshheading:7518621-Mice,
pubmed-meshheading:7518621-Molecular Sequence Data,
pubmed-meshheading:7518621-Nitric Oxide Synthase,
pubmed-meshheading:7518621-Promoter Regions, Genetic,
pubmed-meshheading:7518621-RNA, Messenger,
pubmed-meshheading:7518621-Transcription, Genetic
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pubmed:year |
1993
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pubmed:articleTitle |
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon-gamma and bacterial lipopolysaccharide.
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pubmed:affiliation |
Department of Medicine, Cornell University Medical College, New York, NY.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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