rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
2
|
pubmed:dateCreated |
1994-8-12
|
pubmed:abstractText |
Leucine enkephalin (Leu-enk) was coupled to both T and B cell antibodies in order to investigate the possibility of enhanced immunogenicity via targeted immunization. The two antibodies used were Hm x Mo CD3 and Gt x Mo Ig, respectively. The data indicate that while both antibody carriers enhanced the immunogenicity of Leu-enk, the use of the Hm x Mo CD3 antibody resulted in a greater number of mice with positive Leu-enk specific serum titers. 12 Leu-enk cell lines were produced and one, LE4H8, was chosen for characterization.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jun
|
pubmed:issn |
0022-1759
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
24
|
pubmed:volume |
172
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
165-72
|
pubmed:dateRevised |
2007-11-14
|
pubmed:meshHeading |
pubmed-meshheading:7518482-Amino Acid Sequence,
pubmed-meshheading:7518482-Animals,
pubmed-meshheading:7518482-Antibodies, Anti-Idiotypic,
pubmed-meshheading:7518482-Antibody Affinity,
pubmed-meshheading:7518482-Antigens, CD3,
pubmed-meshheading:7518482-B-Lymphocytes,
pubmed-meshheading:7518482-Enkephalin, Leucine,
pubmed-meshheading:7518482-Epitopes,
pubmed-meshheading:7518482-Female,
pubmed-meshheading:7518482-Kinetics,
pubmed-meshheading:7518482-Mice,
pubmed-meshheading:7518482-Mice, Inbred A,
pubmed-meshheading:7518482-Mice, Inbred BALB C,
pubmed-meshheading:7518482-Mice, Nude,
pubmed-meshheading:7518482-Molecular Sequence Data,
pubmed-meshheading:7518482-Stimulation, Chemical,
pubmed-meshheading:7518482-T-Lymphocytes, Helper-Inducer
|
pubmed:year |
1994
|
pubmed:articleTitle |
Enhanced immunogenicity of leucine enkephalin following coupling to anti-immunoglobulin and anti-CD3 antibodies.
|
pubmed:affiliation |
Department of Chemistry, University of Kansas, Lawrence 66045.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|