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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-8-1
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pubmed:abstractText |
The effects of the serine/threonine phosphatase inhibitors calyculin A, okadaic acid and the calmodulin antagonist W-7 on amylase secretion were studied in pancreatic acini. Calyculin A and okadaic acid dose-dependently inhibited amylase secretion to basal levels when stimulated with the intracellularly acting secretagogues thapsigargin, 8-br-cAMP or PMA. W-7 dose-dependently inhibited thapsigargin- or 8-br-cAMP-induced amylase secretion. In combination, thapsigargin, 8-br-cAMP and PMA induced amylase secretion comparable to the stimulation by cholecystokinin. Their effect was significantly inhibited by calyculin A, okadaic acid or W-7. These data imply that type 1- and 2b-phosphatases and calmodulin play a key role in the stimulation of exocrine pancreatic secretion at a distal step of both the Ca2+/IP3- and cAMP-mediated signal-transduction pathways.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/8-Bromo Cyclic Adenosine...,
http://linkedlifedata.com/resource/pubmed/chemical/Amylases,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Ethers, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Inositol 1,4,5-Trisphosphate,
http://linkedlifedata.com/resource/pubmed/chemical/Okadaic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Oxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Terpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate,
http://linkedlifedata.com/resource/pubmed/chemical/Thapsigargin,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoactive Intestinal Peptide,
http://linkedlifedata.com/resource/pubmed/chemical/W 7,
http://linkedlifedata.com/resource/pubmed/chemical/calyculin A
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
201
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1470-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7517670-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:7517670-Amylases,
pubmed-meshheading:7517670-Animals,
pubmed-meshheading:7517670-Calcium,
pubmed-meshheading:7517670-Cyclic AMP,
pubmed-meshheading:7517670-Ethers, Cyclic,
pubmed-meshheading:7517670-Inositol 1,4,5-Trisphosphate,
pubmed-meshheading:7517670-Male,
pubmed-meshheading:7517670-Okadaic Acid,
pubmed-meshheading:7517670-Oxazoles,
pubmed-meshheading:7517670-Pancreas,
pubmed-meshheading:7517670-Rats,
pubmed-meshheading:7517670-Rats, Wistar,
pubmed-meshheading:7517670-Secretory Rate,
pubmed-meshheading:7517670-Signal Transduction,
pubmed-meshheading:7517670-Sulfonamides,
pubmed-meshheading:7517670-Terpenes,
pubmed-meshheading:7517670-Tetradecanoylphorbol Acetate,
pubmed-meshheading:7517670-Thapsigargin,
pubmed-meshheading:7517670-Vasoactive Intestinal Peptide
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pubmed:year |
1994
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pubmed:articleTitle |
Calyculin A, okadaic acid and W-7 interfere with a distal step in pancreatic acinar signal transduction.
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pubmed:affiliation |
I. Department of Medicine, Christian-Albrechts-University, Kiel, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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