| pubmed-article:7515728 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7515728 | lifeskim:mentions | umls-concept:C0029016 | lld:lifeskim |
| pubmed-article:7515728 | lifeskim:mentions | umls-concept:C1519670 | lld:lifeskim |
| pubmed-article:7515728 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:7515728 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:7515728 | pubmed:dateCreated | 1994-7-11 | lld:pubmed |
| pubmed-article:7515728 | pubmed:abstractText | The formation of new blood vessels is an essential process in embryonic development and wound healing, for tumor growth and metastasis. In situ hybridization studies have revealed that the protooncogene c-est1 is expressed in endothelial cells at the beginning of blood vessel formation, in normal and pathological conditions. c-ets1 encodes a transcription factor, a protein which binds specifically to DNA and which regulates the transcription of genes containing these specific binding sequences in their promotors. Thus, in vitro experiments suggest that c-ets1 may activate the transcription of genes encoding collagenase 1, stromelysine 1 and urokinase plasminogen activator, proteases involved in extracellular matrix degradation. A working hypothesis is that c-ets1 takes part in regulating angiogenesis by controlling the transcription of these genes whose activity is necessary for the migration of endothelial cells from pre-existing capillaries. This hypothesis is discussed with respect to current experimental evidence and to the complexity of the regulatory network controlling gene transcription and extracellular matrix degradation. | lld:pubmed |
| pubmed-article:7515728 | pubmed:language | fre | lld:pubmed |
| pubmed-article:7515728 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515728 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:7515728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515728 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515728 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7515728 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:7515728 | pubmed:issn | 0007-4551 | lld:pubmed |
| pubmed-article:7515728 | pubmed:author | pubmed-author:VandenbunderB... | lld:pubmed |
| pubmed-article:7515728 | pubmed:author | pubmed-author:StehelinDD | lld:pubmed |
| pubmed-article:7515728 | pubmed:author | pubmed-author:WernertNN | lld:pubmed |
| pubmed-article:7515728 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7515728 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:7515728 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7515728 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7515728 | pubmed:pagination | 38-49 | lld:pubmed |
| pubmed-article:7515728 | pubmed:dateRevised | 2009-11-11 | lld:pubmed |
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| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:meshHeading | pubmed-meshheading:7515728-... | lld:pubmed |
| pubmed-article:7515728 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:7515728 | pubmed:articleTitle | [Does oncogene c-ets 1 participate in the regulation of tumor angiogenesis?]. | lld:pubmed |
| pubmed-article:7515728 | pubmed:affiliation | Laboratoire d'oncologie moléculaire, CNRS URA 1160, Institut Pasteur de Lille, France. | lld:pubmed |
| pubmed-article:7515728 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7515728 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:7515728 | pubmed:publicationType | English Abstract | lld:pubmed |
| pubmed-article:7515728 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:7515728 | lld:pubmed |
