Linked Life Data

7515728

Source:http://linkedlifedata.com/resource/pubmed/id/7515728

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-7-11
pubmed:abstractText
The formation of new blood vessels is an essential process in embryonic development and wound healing, for tumor growth and metastasis. In situ hybridization studies have revealed that the protooncogene c-est1 is expressed in endothelial cells at the beginning of blood vessel formation, in normal and pathological conditions. c-ets1 encodes a transcription factor, a protein which binds specifically to DNA and which regulates the transcription of genes containing these specific binding sequences in their promotors. Thus, in vitro experiments suggest that c-ets1 may activate the transcription of genes encoding collagenase 1, stromelysine 1 and urokinase plasminogen activator, proteases involved in extracellular matrix degradation. A working hypothesis is that c-ets1 takes part in regulating angiogenesis by controlling the transcription of these genes whose activity is necessary for the migration of endothelial cells from pre-existing capillaries. This hypothesis is discussed with respect to current experimental evidence and to the complexity of the regulatory network controlling gene transcription and extracellular matrix degradation.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0007-4551
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
38-49
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed-meshheading:7515728-Animals, pubmed-meshheading:7515728-Chick Embryo, pubmed-meshheading:7515728-Endopeptidases, pubmed-meshheading:7515728-Endothelium, Vascular, pubmed-meshheading:7515728-Extracellular Matrix, pubmed-meshheading:7515728-Gene Expression Regulation, Neoplastic, pubmed-meshheading:7515728-Humans, pubmed-meshheading:7515728-Models, Biological, pubmed-meshheading:7515728-Models, Genetic, pubmed-meshheading:7515728-Neoplasm Invasiveness, pubmed-meshheading:7515728-Neoplasms, pubmed-meshheading:7515728-Neoplasms, Experimental, pubmed-meshheading:7515728-Neovascularization, Pathologic, pubmed-meshheading:7515728-Oncogenes, pubmed-meshheading:7515728-Retroviridae Proteins, Oncogenic, pubmed-meshheading:7515728-Transcription, Genetic, pubmed-meshheading:7515728-Transcription Factors
pubmed:year
1993
pubmed:articleTitle
[Does oncogene c-ets 1 participate in the regulation of tumor angiogenesis?].
pubmed:affiliation
Laboratoire d'oncologie moléculaire, CNRS URA 1160, Institut Pasteur de Lille, France.
pubmed:publicationType
Journal Article, In Vitro, English Abstract, Research Support, Non-U.S. Gov't