| pubmed-article:7515715 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0869010 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0013935 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0920288 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:7515715 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:7515715 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:7515715 | pubmed:dateCreated | 1994-7-12 | lld:pubmed |
| pubmed-article:7515715 | pubmed:abstractText | The Wsh is a mutant allele at the W (c-kit) locus of mice, but no significant abnormalities are found at the coding region of the Wsh allele. Since cultured mast cells derived from the spleen of Wsh/Wsh mice do not express messenger RNA (mRNA) of c-kit, we studied the interrelation between the number of mast cells and the magnitude of c-kit mRNA expression in the skin of Wsh/Wsh mice of various ages. The number of mast cells in the skin of Wsh/Wsh embryos of 18 days postcoitum (pc) was approximately 40% that of normal control (+/+) embryos, but the number of mast cells decreased exponentially after birth; the number dropped to 0.6% that of +/+ mice at day 150 after birth. A weak but apparent signal of c-kit mRNA was detectable in the skin of 18-day pc Wsh/Wsh embryos by RNase protection assay but not in the skin of 5-day-old Wsh/Wsh mice. The number of c-kit protein-containing cells was significantly greater in the skin of 18-day pc Wsh/Wsh embryos than in the skin of 5-day-old Wsh/Wsh mice. The abolishment of c-kit mRNA expression appeared to be specific, because the expression of mast cell carboxypeptidase A mRNA but not of c-kit mRNA was detectable by in situ hybridization in skin mast cells of 5-day-old Wsh/Wsh mice. Taken together, the expression of c-kit mRNA was abolished first, then the content of c-kit protein dropped to undetectable levels, and then the disappearance of Wsh/Wsh mast cells themselves followed. | lld:pubmed |
| pubmed-article:7515715 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7515715 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7515715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7515715 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7515715 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:7515715 | pubmed:issn | 0006-4971 | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:TsujimuraTT | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:KitamuraYY | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:NomuraSS | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:YamazakiMM | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:OnoueHH | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:MoriiEE | lld:pubmed |
| pubmed-article:7515715 | pubmed:author | pubmed-author:IsozakiKK | lld:pubmed |
| pubmed-article:7515715 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7515715 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:7515715 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:7515715 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7515715 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:7515715 | pubmed:pagination | 3509-16 | lld:pubmed |
| pubmed-article:7515715 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:7515715 | pubmed:meshHeading | pubmed-meshheading:7515715-... | lld:pubmed |
| pubmed-article:7515715 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7515715 | pubmed:articleTitle | C-kit gene is expressed by skin mast cells in embryos but not in puppies of Wsh/Wsh mice: age-dependent abolishment of c-kit gene expression. | lld:pubmed |
| pubmed-article:7515715 | pubmed:affiliation | Department of Pathology, Osaka University Medical School, Japan. | lld:pubmed |
| pubmed-article:7515715 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7515715 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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