Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5164
pubmed:dateCreated
1994-6-29
pubmed:abstractText
The low density lipoprotein receptor-related protein (LRP) has been proposed to mediate in concert with the LDL receptor (LDLR) the uptake of dietary lipoproteins into the hepatocytes. This hypothesis was tested by transient inactivation of LRP in vivo. Receptor-associated protein (RAP), a dominant negative regulator of LRP function, was transferred by an adenoviral vector to the livers of mice lacking LDLR (LDLR-/-). The inactivation of LRP by RAP was associated with a marked accumulation of chylomicron remnants in LDLR-/- mice and to a lesser degree in normal mice, suggesting that both LDLR and LRP are involved in remnant clearance.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein B-48, http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B, http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins, http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, http://linkedlifedata.com/resource/pubmed/chemical/Chylomicrons, http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins, http://linkedlifedata.com/resource/pubmed/chemical/LDL-Receptor Related..., http://linkedlifedata.com/resource/pubmed/chemical/Low Density Lipoprotein..., http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic, http://linkedlifedata.com/resource/pubmed/chemical/Receptors, LDL, http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides, http://linkedlifedata.com/resource/pubmed/chemical/alpha-Macroglobulins
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0036-8075
pubmed:author
pubmed:issnType
Print
pubmed:day
3
pubmed:volume
264
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1471-4
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:7515194-Adenoviridae, pubmed-meshheading:7515194-Animals, pubmed-meshheading:7515194-Apolipoprotein B-48, pubmed-meshheading:7515194-Apolipoproteins B, pubmed-meshheading:7515194-Carrier Proteins, pubmed-meshheading:7515194-Cholesterol, pubmed-meshheading:7515194-Chylomicrons, pubmed-meshheading:7515194-Gene Transfer Techniques, pubmed-meshheading:7515194-Genetic Vectors, pubmed-meshheading:7515194-Glycoproteins, pubmed-meshheading:7515194-LDL-Receptor Related Protein-Associated Protein, pubmed-meshheading:7515194-Liver, pubmed-meshheading:7515194-Low Density Lipoprotein Receptor-Related Protein-1, pubmed-meshheading:7515194-Male, pubmed-meshheading:7515194-Mice, pubmed-meshheading:7515194-Mice, Inbred C57BL, pubmed-meshheading:7515194-Receptors, Immunologic, pubmed-meshheading:7515194-Receptors, LDL, pubmed-meshheading:7515194-Triglycerides, pubmed-meshheading:7515194-alpha-Macroglobulins
pubmed:year
1994
pubmed:articleTitle
Inhibition of hepatic chylomicron remnant uptake by gene transfer of a receptor antagonist.
pubmed:affiliation
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75235.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't