Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-6-28
|
| pubmed:abstractText |
We measured hepatitis C virus (HCV) RNA and antibodies against HCV recombinant proteins (C22/S1, E1/S2, E2/NS1, C33/NS3, C100/NS4, NS5) in serial serum samples from 22 interferon-treated patients with a long-term follow up (range: 36-44 months). Eleven of them showed persistently normal liver function tests and a significant histological amelioration or a complete resolution of chronic hepatitis (long-term responders, LTRs). In the remaining 11 patients (non-responders (NRs)) liver function tests normalized temporarily during therapy or remained unchanged. At the end of the follow up (3 years), viraemia was undetectable in six of 11 LTRs (54.6%). HCV-RNA was always detectable in the serum of NRs (p = 0.017). At admission, anti-C22/S1, anti-E1/S2, anti-E2/NS1, anti-C33/NS3, anti-C100/NS4 and anti-NS5 were detected in 95.4%, 40.9%, 77.3%, 95.4%, 72.7% and 77.3% of the patients, respectively. Three years after suspension of therapy, anti-C100/NS4 was undetectable in five of six (83.3%) LTRs who cleared HCV-RNA and in only one with ongoing viraemia (20%). Anti-E2/NS1 was undetectable in 54.5% of LTRs and in no NRs (p = 0.067). Anti-E1/S2 was detected more frequently in LTRs than in NRs (81.8% vs 45.5%). Serum levels of anti-C22/S1, C33/NS3 and NS5 did not change during therapy and the follow up in either group of patients. The clearance of viraemia in LTRs was associated with that of anti-C100/NS4 (p = 0.017). Serum HCV-RNA and anti-C100/NS4 appear suitable tools for monitoring patients who respond to therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis C Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Core Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/core protein p22, Hepatitis C virus,
http://linkedlifedata.com/resource/pubmed/chemical/interferon alfa-2b,
http://linkedlifedata.com/resource/pubmed/chemical/nucleocapsid protein, Hepatitis C...
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0106-9543
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
65-70
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7515141-Adult,
pubmed-meshheading:7515141-Base Sequence,
pubmed-meshheading:7515141-Female,
pubmed-meshheading:7515141-Follow-Up Studies,
pubmed-meshheading:7515141-Hepacivirus,
pubmed-meshheading:7515141-Hepatitis, Chronic,
pubmed-meshheading:7515141-Hepatitis Antibodies,
pubmed-meshheading:7515141-Hepatitis C,
pubmed-meshheading:7515141-Hepatitis C Antibodies,
pubmed-meshheading:7515141-Hepatitis C Antigens,
pubmed-meshheading:7515141-Humans,
pubmed-meshheading:7515141-Interferon-alpha,
pubmed-meshheading:7515141-Male,
pubmed-meshheading:7515141-Middle Aged,
pubmed-meshheading:7515141-Molecular Sequence Data,
pubmed-meshheading:7515141-RNA, Viral,
pubmed-meshheading:7515141-Recombinant Proteins,
pubmed-meshheading:7515141-Viral Core Proteins,
pubmed-meshheading:7515141-Viral Proteins,
pubmed-meshheading:7515141-Viremia
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Hepatitis C virus markers in patients with long-term biochemical and histological remission of chronic hepatitis.
|
| pubmed:affiliation |
Department of Gastroenterology, Molinette Hospital, Turin, Italy.
|
| pubmed:publicationType |
Journal Article
|