rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1994-6-20
|
pubmed:abstractText |
The inducible isoform of nitric oxide synthase has been detected in cytomegalovirus (CMV)-infected retinas from acquired immunodeficiency syndrome (AIDS) patients by immunohistochemistry and NADPH-diaphorase staining. Subsequent immunohistochemistry using antibodies against CMV antigens and glial fibrillary acidic protein (GFAP) demonstrated that inducible NOS was localized in CMV-infected glial cells, particularly Müller cells. These findings indicate that inducible NOS is expressed in vivo in the human retina as a result of viral infection, and suggest that high levels of NO production might be involved in CMV-induced retinitis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0304-3940
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
17
|
pubmed:volume |
166
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
31-4
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:7514775-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7514775-Amino Acid Oxidoreductases,
pubmed-meshheading:7514775-Cytomegalovirus Retinitis,
pubmed-meshheading:7514775-Enzyme Induction,
pubmed-meshheading:7514775-Glial Fibrillary Acidic Protein,
pubmed-meshheading:7514775-Humans,
pubmed-meshheading:7514775-Immunohistochemistry,
pubmed-meshheading:7514775-In Situ Hybridization,
pubmed-meshheading:7514775-NADPH Dehydrogenase,
pubmed-meshheading:7514775-Neuroglia,
pubmed-meshheading:7514775-Nitric Oxide Synthase,
pubmed-meshheading:7514775-Retina
|
pubmed:year |
1994
|
pubmed:articleTitle |
Expression of inducible nitric oxide synthase in cytomegalovirus-infected glial cells of retinas from AIDS patients.
|
pubmed:affiliation |
Unité de Recherches Gérontologiques, INSERM U118, Association Claude Bernard, Paris, France.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|