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pubmed-article:7514455pubmed:abstractTextOlfactory transduction proceeds through a G-protein coupled cascade that produces the ubiquitous second messenger cyclic AMP. The cyclic AMP causes a change in membrane potential by acting directly on an ion channel that allows cations to flow into the cell. This ion channel is one of a new family of ion channels that are activated by intracellular cyclic nucleotides. However, even though they are activated by binding a ligand their amino acid structure shows that they share a common ancestry with voltage activated channels, especially voltage dependent Ca2+ channels. In olfactory neurons these channels perform a critical role in the transduction of chemical information in the environment into changes in membrane electrical properties that are transmitted to higher order processing centers in the brain.lld:pubmed
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pubmed-article:7514455pubmed:articleTitleThe cyclic nucleotide gated channel of olfactory receptor neurons.lld:pubmed
pubmed-article:7514455pubmed:affiliationDepartment of Biological Sciences, Columbia University, New York, NY 10027.lld:pubmed
pubmed-article:7514455pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:7514455pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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