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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-6-23
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pubmed:abstractText |
Olfactory transduction proceeds through a G-protein coupled cascade that produces the ubiquitous second messenger cyclic AMP. The cyclic AMP causes a change in membrane potential by acting directly on an ion channel that allows cations to flow into the cell. This ion channel is one of a new family of ion channels that are activated by intracellular cyclic nucleotides. However, even though they are activated by binding a ligand their amino acid structure shows that they share a common ancestry with voltage activated channels, especially voltage dependent Ca2+ channels. In olfactory neurons these channels perform a critical role in the transduction of chemical information in the environment into changes in membrane electrical properties that are transmitted to higher order processing centers in the brain.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Calcium Channel Blockers,
http://linkedlifedata.com/resource/pubmed/chemical/Cations, Divalent,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic GMP,
http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1043-4682
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
39-46
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7514455-Animals,
pubmed-meshheading:7514455-Calcium Channel Blockers,
pubmed-meshheading:7514455-Cations, Divalent,
pubmed-meshheading:7514455-Cyclic AMP,
pubmed-meshheading:7514455-Cyclic GMP,
pubmed-meshheading:7514455-Ion Channel Gating,
pubmed-meshheading:7514455-Ion Channels,
pubmed-meshheading:7514455-Models, Neurological,
pubmed-meshheading:7514455-Olfactory Receptor Neurons,
pubmed-meshheading:7514455-Second Messenger Systems
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pubmed:year |
1994
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pubmed:articleTitle |
The cyclic nucleotide gated channel of olfactory receptor neurons.
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pubmed:affiliation |
Department of Biological Sciences, Columbia University, New York, NY 10027.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Review
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