rdf:type |
|
lifeskim:mentions |
umls-concept:C0001613,
umls-concept:C0007776,
umls-concept:C0017725,
umls-concept:C0022655,
umls-concept:C0041625,
umls-concept:C0051318,
umls-concept:C0147003,
umls-concept:C0175677,
umls-concept:C0205263,
umls-concept:C0302583,
umls-concept:C0521390,
umls-concept:C0599946,
umls-concept:C0871712
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pubmed:issue |
1
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pubmed:dateCreated |
1994-6-16
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pubmed:abstractText |
The vitamin E analog, trolox, protected cultured cortical neurons against damage induced by exposure to either iron ions or ultraviolet (UV) light, consistent with an ability to inhibit free radical-mediated cytotoxicity. Trolox also reduced neuronal death induced by 24 h exposure to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), but not that induced by N-methyl-D-aspartate (NMDA). When combined with the NMDA receptor antagonist dextrorphan, trolox also reduced the neuronal injury induced by glucose deprivation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/6-hydroxy-2,5,7,8-tetramethylchroman...,
http://linkedlifedata.com/resource/pubmed/chemical/Chromans,
http://linkedlifedata.com/resource/pubmed/chemical/Dextrorphan,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Combinations,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Iron,
http://linkedlifedata.com/resource/pubmed/chemical/Vitamin E,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Amino-3-hydroxy-5-methyl-4-iso...
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0006-8993
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
7
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pubmed:volume |
639
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
102-8
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7514085-Animals,
pubmed-meshheading:7514085-Cells, Cultured,
pubmed-meshheading:7514085-Cerebral Cortex,
pubmed-meshheading:7514085-Chromans,
pubmed-meshheading:7514085-Dextrorphan,
pubmed-meshheading:7514085-Drug Combinations,
pubmed-meshheading:7514085-Glucose,
pubmed-meshheading:7514085-Iron,
pubmed-meshheading:7514085-Mice,
pubmed-meshheading:7514085-Neuroglia,
pubmed-meshheading:7514085-Neurons,
pubmed-meshheading:7514085-Ultraviolet Rays,
pubmed-meshheading:7514085-Vitamin E,
pubmed-meshheading:7514085-alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
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pubmed:year |
1994
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pubmed:articleTitle |
Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA.
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pubmed:affiliation |
Department of Neurology and Neurological Sciences, Stanford University, CA 94305.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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