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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1994-6-8
|
| pubmed:abstractText |
15-Desmethyl FK-506 and 15,31-desmethyl FK-506 metabolites extracted from incubated human liver microsomes were separated by normal and reversed-phase HPLC. The metabolites were identified by fast atom bombardment/mass spectrometry and nuclear magnetic resonance spectroscopy. The in vitro 50% inhibitory concentration, tested against bidirectional mixed lymphocyte reactions, was 325 mg/L for 15,31-desmethyl FK-506 and 4 mg/L for 15-desmethyl FK-506, indicating that these products of FK-506 demethylation retain in vitro immunosuppressive activity.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0009-9147
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
40
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
740-4
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:7513627-Chromatography, High Pressure Liquid,
pubmed-meshheading:7513627-Humans,
pubmed-meshheading:7513627-Immunosuppression,
pubmed-meshheading:7513627-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:7513627-Magnetic Resonance Spectroscopy,
pubmed-meshheading:7513627-Methylation,
pubmed-meshheading:7513627-Microsomes, Liver,
pubmed-meshheading:7513627-Spectrometry, Mass, Fast Atom Bombardment,
pubmed-meshheading:7513627-Tacrolimus
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
15-Desmethyl FK-506 and 15,31-desmethyl FK-506 from human liver microsomes: isolation, identification (by fast atom bombardment mass spectrometry and NMR), and evaluation of in vitro immunosuppressive activity.
|
| pubmed:affiliation |
Department of Pharmaceutical Sciences, UCL, FATC, Brussels, Belgium.
|
| pubmed:publicationType |
Journal Article
|