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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1994-6-1
|
| pubmed:databankReference | |
| pubmed:abstractText |
The cDNA sequences of chicken and hagfish prothrombin have been determined. The sequences predict that prothrombin from both species is synthesized as a prepro-protein consisting of a putative Gla domain, two kringle domains, and a two-chain protease domain. Chicken and hagfish prothrombin share 51.6% amino acid sequence identity (313/627 residues). Both chicken and hagfish prothrombin are structurally very similar to human, bovine, rat, and mouse prothrombin and all six species share 41% amino acid sequence identity. Amino acid sequence alignments of human, bovine, rat, mouse, chicken, and hagfish prothrombin suggest that the thrombin B-chain and the propeptide-Gla domain are the regions most constrained for the common function(s) of vertebrate prothrombins.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0022-2844
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
38
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
177-87
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:7513365-Amino Acid Sequence,
pubmed-meshheading:7513365-Animals,
pubmed-meshheading:7513365-Base Sequence,
pubmed-meshheading:7513365-Biological Evolution,
pubmed-meshheading:7513365-Chickens,
pubmed-meshheading:7513365-Cloning, Molecular,
pubmed-meshheading:7513365-DNA, Complementary,
pubmed-meshheading:7513365-Gene Library,
pubmed-meshheading:7513365-Hagfishes,
pubmed-meshheading:7513365-Molecular Sequence Data,
pubmed-meshheading:7513365-Peptide Fragments,
pubmed-meshheading:7513365-Protein Structure, Secondary,
pubmed-meshheading:7513365-Prothrombin,
pubmed-meshheading:7513365-RNA,
pubmed-meshheading:7513365-Restriction Mapping,
pubmed-meshheading:7513365-Sequence Alignment,
pubmed-meshheading:7513365-Sequence Analysis,
pubmed-meshheading:7513365-Sequence Homology, Amino Acid
|
| pubmed:year |
1994
|
| pubmed:articleTitle |
Evolution of prothrombin: isolation and characterization of the cDNAs encoding chicken and hagfish prothrombin.
|
| pubmed:affiliation |
Department of Biochemistry, University of British Columbia, Vancouver, Canada.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|