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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1A
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pubmed:dateCreated |
1994-5-26
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pubmed:abstractText |
An angiogenic inhibitor, TNP-470, is an analogue of fumagillin. This study reports the effects of TNP-470 and bromocriptine on the normal pituitary glands and estrogen-induced rat pituitary tumors. TNP-470 inhibited the increase of normal pituitary weight and the tumorigenesis induced by estrogen. The decreased labelling index in the pituitary cells, showed that TNP-470 may suppress the activity of cell proliferation as the result of anti-angiogenesis. Combination treatment with TNP-470 and bromocriptine was much more effective than TNP alone. These results suggest that TNP-470 is a potentially beneficial drug for pituitary tumors.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0250-7005
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7513141-Animals,
pubmed-meshheading:7513141-Antibiotics, Antineoplastic,
pubmed-meshheading:7513141-Body Weight,
pubmed-meshheading:7513141-Cell Division,
pubmed-meshheading:7513141-Cyclohexanes,
pubmed-meshheading:7513141-Disease Models, Animal,
pubmed-meshheading:7513141-Estrogen Antagonists,
pubmed-meshheading:7513141-Estrogens,
pubmed-meshheading:7513141-Female,
pubmed-meshheading:7513141-Neoplasms, Hormone-Dependent,
pubmed-meshheading:7513141-Neovascularization, Pathologic,
pubmed-meshheading:7513141-Organ Size,
pubmed-meshheading:7513141-Pituitary Gland,
pubmed-meshheading:7513141-Pituitary Neoplasms,
pubmed-meshheading:7513141-Prolactin,
pubmed-meshheading:7513141-Rats,
pubmed-meshheading:7513141-Rats, Inbred F344,
pubmed-meshheading:7513141-Sesquiterpenes
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pubmed:articleTitle |
Inhibitory effect of TNP-470, a new anti-angiogenic agent, on the estrogen induced rat pituitary tumors.
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pubmed:affiliation |
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
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