| pubmed-article:7512609 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0014834 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0003250 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0032594 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0023810 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0036983 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0441655 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:7512609 | lifeskim:mentions | umls-concept:C0444669 | lld:lifeskim |
| pubmed-article:7512609 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:7512609 | pubmed:dateCreated | 1994-5-17 | lld:pubmed |
| pubmed-article:7512609 | pubmed:abstractText | Monoclonal antibodies (MAbs) specific for O polysaccharide or core oligosaccharide/lipid A of Escherichia coli O111:B4 lipopolysaccharide (LPS) were compared in canine septic shock. Animals received O-specific, core-specific, or control murine IgG2a MAbs (or saline) before intraperitoneal implantation of an E. coli O111:B4-infected clot. Animals were further randomized to ceftriaxone or saline. O-specific MAb significantly reduced bacteremia and endotoxemia but not serum tumor necrosis factor. Core-specific MAb significantly increased mean arterial pressure from day 4 to 28 (P = .02). In dogs not receiving ceftriaxone, survival was enhanced by O-specific MAb (4/5) compared with core-specific MAb (0/5) and control (1/8) (P = .03). Survival rates were similar (P = .22) but survival was prolonged in antibiotic-treated animals also receiving O-specific MAb (P = .02 vs. core-specific MAb and controls) or core-specific MAb (P = .08 vs. controls). These data support the complex role of LPS in sepsis and the discrete functional effects of MAbs specific for different elements of LPS. | lld:pubmed |
| pubmed-article:7512609 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:language | eng | lld:pubmed |
| pubmed-article:7512609 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:7512609 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:7512609 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:7512609 | pubmed:issn | 0022-1899 | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:DannerR LRL | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:PollackMM | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:HoffmanW DWD | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:SolomonM AMA | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:KolevAA | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:BadveV MVM | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:GueldeGG | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:MouginisTT | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:YatsivII | lld:pubmed |
| pubmed-article:7512609 | pubmed:author | pubmed-author:KoevL ALA | lld:pubmed |
| pubmed-article:7512609 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:7512609 | pubmed:volume | 169 | lld:pubmed |
| pubmed-article:7512609 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:7512609 | pubmed:authorsComplete | N | lld:pubmed |
| pubmed-article:7512609 | pubmed:pagination | 553-61 | lld:pubmed |
| pubmed-article:7512609 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:7512609 | pubmed:meshHeading | pubmed-meshheading:7512609-... | lld:pubmed |
| pubmed-article:7512609 | pubmed:meshHeading | pubmed-meshheading:7512609-... | lld:pubmed |
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| pubmed-article:7512609 | pubmed:meshHeading | pubmed-meshheading:7512609-... | lld:pubmed |
| pubmed-article:7512609 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:7512609 | pubmed:articleTitle | Distinct functional activities in canine septic shock of monoclonal antibodies specific for the O polysaccharide and core regions of Escherichia coli lipopolysaccharide. | lld:pubmed |
| pubmed-article:7512609 | pubmed:affiliation | Critical Care Medicine Department, National Institutes of Health, Bethesda, Maryland 20892. | lld:pubmed |
| pubmed-article:7512609 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:7512609 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:7512609 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:7512609 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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