Linked Life Data

7512039

Source:http://linkedlifedata.com/resource/pubmed/id/7512039

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1994-5-12
pubmed:abstractText
The role of nitric oxide in peristalsis was studied by using NG-nitro-L-arginine, an inhibitor of the biosynthesis of nitric oxide, in the isolated guinea-pig ileum. Constant peristalsis was cyclically induced by distending the ileal wall with intraluminal solution infused at a constant rate. NG-Nitro-L-arginine (10(-6) to 10(-4) M) dose dependently increased the frequency of peristalsis. This effect of NG-nitro-L-arginine was almost hindered by pretreating the ileum with 10(-3) M L-arginine, but not D-arginine. Nitroprusside (5 X 10(-7) M) reversed the frequency increase. In the presence of NG-nitro-L-arginine, peristaltic propulsion occurred at a smaller distension of the ileal wall and the ileum constricted to a smaller diameter at the completion of propulsion. The rate of shortening of longitudinal muscle during distension was raised by NG-nitro-L-arginine, although the peak magnitudes were not changed. Consistent with these effects of NG-nitro-L-arginine on peristalsis, NG-nitro-L-arginine at 10(-5) M increased the contractions of circular muscle in response to electrical field stimulation, but not those of longitudinal muscle. These results suggest that endogenous nitric oxide modulates peristalsis by limiting the contractile activity of the circular muscle of the guinea-pig ileum.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
14
pubmed:volume
251
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
221-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Role of nitric oxide in the peristalsis in the isolated guinea-pig ileum.
pubmed:affiliation
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.
pubmed:publicationType
Journal Article, In Vitro