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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
1994-5-5
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pubmed:databankReference |
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pubmed:abstractText |
We used the polymerase chain reaction with degenerate oligonucleotide primers to search for Csk-related kinases. A cDNA coding for a Csk-like protein-tyrosine kinase was cloned from mouse brain and was designated ctk, for csk-type protein-tyrosine kinase. The 1.9-kb ctk mRNA was found to be expressed predominantly in brain and capable of encoding a 52-kDa protein-tyrosine kinase. The amino acid sequence of Ctk was found to possess 53% identity with mouse Csk, shared all the predicted structural features of Csk, and was capable of phosphorylating the carboxyl-terminal conserved tyrosine of Src family members. Our results thereby indicate that ctk represents a gene that defines a family of structurally and functionally related Csk-like protein-tyrosine kinases.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1281458,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1371489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1372437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1639064,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1709258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1714601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1722201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1846320,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-1945408,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-2448318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-2479826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-2480346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-3030562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-3262426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-3291115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-3754329,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-7685657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-8251750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-8366126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-8371758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511815-8513497
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
29
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pubmed:volume |
91
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2597-601
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pubmed:dateRevised |
2011-11-2
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pubmed:meshHeading |
pubmed-meshheading:7511815-Amino Acid Sequence,
pubmed-meshheading:7511815-Animals,
pubmed-meshheading:7511815-Base Sequence,
pubmed-meshheading:7511815-Brain,
pubmed-meshheading:7511815-Cloning, Molecular,
pubmed-meshheading:7511815-Mice,
pubmed-meshheading:7511815-Molecular Sequence Data,
pubmed-meshheading:7511815-Phosphorylation,
pubmed-meshheading:7511815-Protein-Tyrosine Kinases,
pubmed-meshheading:7511815-Proto-Oncogene Proteins pp60(c-src),
pubmed-meshheading:7511815-Sequence Homology, Amino Acid,
pubmed-meshheading:7511815-Substrate Specificity,
pubmed-meshheading:7511815-Tissue Distribution
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pubmed:year |
1994
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pubmed:articleTitle |
Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family.
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pubmed:affiliation |
Department of Molecular Biology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543.
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pubmed:publicationType |
Journal Article,
Comparative Study
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