|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0003316,
umls-concept:C0014644,
umls-concept:C0015219,
umls-concept:C0019721,
umls-concept:C0026882,
umls-concept:C0032659,
umls-concept:C0039194,
umls-concept:C0039195,
umls-concept:C0205250,
umls-concept:C0370215,
umls-concept:C0871261,
umls-concept:C0887913,
umls-concept:C1517945,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1709915,
umls-concept:C2911692
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1994-5-5
|
|
pubmed:abstractText |
Epstein-Barr virus (EBV) is a B lymphotropic herpesvirus of humans that elicits strong HLA class I-restricted cytotoxic T lymphocyte (CTL) responses. An influence of such responses on virus evolution was first suggested by our finding that EBV isolates from the highly HLA A11-positive Papua New Guinea (PNG) population carried a lys-thr mutation at residue 424 of the nuclear antigen EBV-encoded nuclear antigen (EBNA4) that destroyed the immunodominant target epitope for A11-restricted CTL recognition. Here we turn to a much larger population, Southern Chinese, where the A11 allele is again present in over 50% of the individuals. Each of 23 EBV isolates analyzed from this population were also mutated in the EBNA4 416-424 epitope, the mutations selectively involving one of the two anchor residues in positions 2 (417 val-leu) or 9 (424 lys-asp, -arg or -thr) that are critical for A11-peptide interaction. The majority of the Chinese isolates and all 10 PNG isolates also carried mutations affecting positions 1 and 2 of the next most immunodominant A11-restricted epitope, EBNA4 residues 399-408. These changes clearly affected antigenicity since A11-positive lymphoblastoid cell lines (LCLs) carrying these mutant EBV strains were not recognized by A11-restricted CTLs raised against the prototype B95.8 virus. Furthermore, Chinese donors naturally infected with these mutant viruses did not mount detectable A11-restricted CTL responses on in vitro stimulation with autologous LCL cells carrying either the B95.8 or their endogenous EBV strain. In two different highly A11-positive populations, therefore, immune pressure appears to have selected for resident EBV strains lacking immunodominant A11-restricted CTL epitopes.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1169135,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1319456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1321426,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1377222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1688611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1695259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1696684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1700303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1721107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-1734720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-2420472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-2426185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-3016710,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-3023050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-3029268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-306072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-3217935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-4346033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-6319303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-649177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-6975300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-7679748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-7688791,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-7693972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7511684-8384718
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
179
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1297-305
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:7511684-Amino Acid Sequence,
pubmed-meshheading:7511684-Base Sequence,
pubmed-meshheading:7511684-Biological Evolution,
pubmed-meshheading:7511684-Burkitt Lymphoma,
pubmed-meshheading:7511684-China,
pubmed-meshheading:7511684-DNA, Viral,
pubmed-meshheading:7511684-Epitopes,
pubmed-meshheading:7511684-Ethnic Groups,
pubmed-meshheading:7511684-HLA-A Antigens,
pubmed-meshheading:7511684-HLA-A11 Antigen,
pubmed-meshheading:7511684-Herpesvirus 4, Human,
pubmed-meshheading:7511684-Humans,
pubmed-meshheading:7511684-Molecular Sequence Data,
pubmed-meshheading:7511684-Mutation,
pubmed-meshheading:7511684-T-Lymphocytes, Cytotoxic
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
T cell responses and virus evolution: loss of HLA A11-restricted CTL epitopes in Epstein-Barr virus isolates from highly A11-positive populations by selective mutation of anchor residues.
|
|
pubmed:affiliation |
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
|
