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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1994-4-25
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pubmed:abstractText |
Peripheral blood mononuclear cells were quantified for the subsets of CD4, CD8, and CD19 lymphocytes by using CD45RA (2H4), CD29(4B4), CD57, CD5, CD10, Leu8, HLA-DR, and TCR gamma delta-1 monoclonal antibodies and dual color immunofluorescence. A comparative analysis of lymphocyte subpopulations was made among 52 HIV-infected and 50 age-matched control children and 30 HIV-seropositive and 27 negative control adults. A significant decrease in the CD4+CD45RA+ "naive" cells was much more marked in HIV-infected children than in HIV-infected adults. A significant percentage increase in the CD4+CD29+ "memory" cells was observed in HIV-infected children but not in infected adults; however, the absolute numbers were usually decreased in all age groups. The mean percentage and absolute numbers of CD4+CD7+ and CD4+Leu8+ cells were decreased in HIV-infected children, although usually not significantly. The CD3+TCR gamma delta-1+ did not show any change in the infected children tested. The mean percentage and absolute number of the CD8+HLA-DR+ cells increased significantly in HIV-infected persons of all ages. The CD8+CD57+ cells were increased in percentage and absolute number in HIV-infected children ages 1-4 and 4-8 years. In the adults, no change was noted in either the percentage or absolute number of CD19+CD5+ B cells, a finding similar to that noted in HIV-infected children above 1 year of age. Although adults showed a significant decrease in both percentage and numbers of CD5- B cells, an increase was noted in the 7- to 12-month-old HIV-infected children. The CD19+CD10+ cells showed a slight but significant decrease in the youngest age group and a significant increase in the older age groups of HIV-infected children. These findings indicate that several lymphocyte subpopulations are altered differentially during HIV infection in children of varying ages and in adults.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD19,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD29,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Neprilysin
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0090-1229
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
71
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:7511082-Adult,
pubmed-meshheading:7511082-Aging,
pubmed-meshheading:7511082-Antigens, CD,
pubmed-meshheading:7511082-Antigens, CD19,
pubmed-meshheading:7511082-Antigens, CD29,
pubmed-meshheading:7511082-Antigens, CD8,
pubmed-meshheading:7511082-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:7511082-B-Lymphocyte Subsets,
pubmed-meshheading:7511082-CD4-Positive T-Lymphocytes,
pubmed-meshheading:7511082-Child,
pubmed-meshheading:7511082-Child, Preschool,
pubmed-meshheading:7511082-HIV Infections,
pubmed-meshheading:7511082-Humans,
pubmed-meshheading:7511082-Immunologic Memory,
pubmed-meshheading:7511082-Infant,
pubmed-meshheading:7511082-Neprilysin,
pubmed-meshheading:7511082-T-Lymphocyte Subsets
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pubmed:year |
1994
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pubmed:articleTitle |
Subpopulations of T and B cells in perinatally HIV-infected and noninfected age-matched children compared with those in adults.
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pubmed:affiliation |
Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30303.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
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