|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5-6
|
|
pubmed:dateCreated |
1994-4-15
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|
pubmed:abstractText |
The fractional contribution of Ca to current flow through neuronal-type nicotinic acetylcholine receptor channels was determined by quantitative fluorescence microfluorimetry using fura-2. The method, which has been applied already to several types of cells and channels is described in detail here. At -70 mV and 2 mM external Ca concentration it was found that Ca contributes 2.5% to the net current. The fractional contribution was found to be voltage dependent, increasing at negative potentials e-fold for a 110 mV potential difference. Total non-specific cation current was found to have a bell-shaped dependence on external Ca concentration peaking at 2 mM.
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|
pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0031-6768
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
425
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
511-7
|
|
pubmed:dateRevised |
2003-11-14
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|
pubmed:meshHeading |
pubmed-meshheading:7510879-Adrenal Glands,
pubmed-meshheading:7510879-Animals,
pubmed-meshheading:7510879-Calcium,
pubmed-meshheading:7510879-Calcium Channels,
pubmed-meshheading:7510879-Cattle,
pubmed-meshheading:7510879-Chromaffin System,
pubmed-meshheading:7510879-Electrophysiology,
pubmed-meshheading:7510879-Fura-2,
pubmed-meshheading:7510879-Ion Channel Gating,
pubmed-meshheading:7510879-Ion Channels,
pubmed-meshheading:7510879-Permeability,
pubmed-meshheading:7510879-Receptors, Nicotinic
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Calcium permeability of nicotinic acetylcholine receptor channels in bovine adrenal chromaffin cells.
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|
pubmed:affiliation |
Department of Medicine, Jewish Hospital of St. Louis, MO 63110.
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|
pubmed:publicationType |
Journal Article
|
