Linked Life Data

7510867

Source:http://linkedlifedata.com/resource/pubmed/id/7510867

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-4-18
pubmed:abstractText
L-selectin is a leukocyte adhesion molecule important in the initial stages of the interaction of neutrophils with endothelium during neutrophil emigration from the bloodstream. Neutrophils and eosinophils from newborn infants express significantly less L-selectin than do neutrophils and eosinophils from adults. It is not known whether L-selectin expression on fetal granulocytes is similarly decreased. We studied fetal blood specimens obtained for a variety of clinical indications by percutaneous umbilical cord sampling at 23 to 34 wk of gestation and measured L-selectin expression by flow cytometry. Eosinophils constituted a large proportion of the granulocytes in these fetal specimens (42 +/- 26%, n = 8), with eosinophil counts ranging from 180 to 690/mm3 (mean +/- SD: 350 +/- 220). There was no difference in L-selectin expression of unstimulated fetal and adult neutrophils (mean +/- SD specific fluorescence: 53.0 +/- 6.8 versus 56.6 +/- 4.3, n = 6), and no difference between unstimulated fetal and adult eosinophils (16.0 +/- 6.5 versus 18.7 +/- 3.2, n = 6). Thus, neutrophils and eosinophils from fetuses as early as 23 wk express L-selectin at adult levels. Furthermore, fetal neutrophils and eosinophils shed the receptor normally in response to stimulation in vitro. We conclude that the reduction of L-selectin expression on neonatal neutrophils and eosinophils is not due to an inherent developmental limitation, but instead must be caused by changes occurring in the neonatal period. Elucidation of the etiology of these changes may aid in the development of therapeutic measures to correct the L-selectin-related defects of neonatal neutrophil adherence.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0031-3998
pubmed:author
pubmed:issnType
Print
pubmed:volume
34
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
253-7
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Fetal neutrophils and eosinophils express normal levels of L-selectin.
pubmed:affiliation
Division of Neonatology, UCLA School of Medicine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't