Linked Life Data

7510770

Source:http://linkedlifedata.com/resource/pubmed/id/7510770

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-4-15
pubmed:abstractText
Insulin-like growth factor-I (IGF-I) and testosterone are major hormonal regulators of protein metabolism. We chose genetically GH-deficient little (lit/lit) mice to test whether these anabolic hormones act independently or in concert with each other to stimulate protein metabolism. Hormones were administered for 14 days at constant rates to 14-week-old lit/lit female mice, IGF-I was infused via mini-osmotic pumps at 30 micrograms/day and testosterone was administered using 30 mg pellets. Food consumption was measured during the experimental period, and at the end we measured: (a) serum IGF-I, IGF-I-binding proteins (IGFBPs) and blood urea nitrogen (BUN); (b) body and musculo-skeletal carcass weights; (c) musculo-skeletal carcass water, fat, protein and mineral; and (d) selected organ weights plus protein and DNA contents. We found that both of these growth-stimulatory hormones, IGF-I and testosterone, alone and in combination, had anabolic effects on different metabolic compartments in specific target organs. The most unexpected finding in this study was that the IGF-I-induced increase in musculo-skeletal carcass weight arose solely from increased water, revealing the importance of this compartment as an early target of IGF-I action. Other effects caused specifically by IGF-I, but not testosterone, included increases in serum IGFBP-3, body weight and spleen weight. The specific effect of testosterone, but not IGF-I, was to increase serum IGFBP-2. Independent effects were induced by each hormone alone for kidney and spleen weight, kidney and spleen protein content and BUN.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0022-0795
pubmed:author
pubmed:issnType
Print
pubmed:volume
139
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
431-9
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:7510770-Animals, pubmed-meshheading:7510770-Body Weight, pubmed-meshheading:7510770-Carrier Proteins, pubmed-meshheading:7510770-Drug Synergism, pubmed-meshheading:7510770-Female, pubmed-meshheading:7510770-Growth Hormone, pubmed-meshheading:7510770-Insulin-Like Growth Factor Binding Protein 2, pubmed-meshheading:7510770-Insulin-Like Growth Factor Binding Proteins, pubmed-meshheading:7510770-Insulin-Like Growth Factor I, pubmed-meshheading:7510770-Kidney, pubmed-meshheading:7510770-Liver, pubmed-meshheading:7510770-Mice, pubmed-meshheading:7510770-Mice, Mutant Strains, pubmed-meshheading:7510770-Muscles, pubmed-meshheading:7510770-Organ Size, pubmed-meshheading:7510770-Proteins, pubmed-meshheading:7510770-Somatomedins, pubmed-meshheading:7510770-Spleen, pubmed-meshheading:7510770-Testosterone, pubmed-meshheading:7510770-Water
pubmed:year
1993
pubmed:articleTitle
Regulation of metabolic water and protein compartments by insulin-like growth factor-I and testosterone in growth hormone-deficient lit/lit mice.
pubmed:affiliation
Jackson Laboratory, Bar Harbor, Maine 04609.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't