Linked Life Data

7510057

Source:http://linkedlifedata.com/resource/pubmed/id/7510057

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-4-4
pubmed:abstractText
It has long been thought that the augmenting effects of E series prostaglandins (PG) are mediated by cyclic AMP (cAMP). In clarifying the validity of this hypothesis, we studied the effects of increases in intracellular cAMP on the heat response of testicular polymodal receptors. Recordings were obtained from testis-spermatic nerve preparations excised from dogs anesthetized with pentobarbital (30 mg/kg, i.v.). Induction of increases in intracellular cAMP by either forskolin, an adenylyl cyclase activator, or a mixture of dibutyryl cAMP (10(-4) M) and 3-isobutyl-1-methyl xanthine (10(-4) M) significantly and reversibly augmented the heat response. These results support the notion that cAMP is involved in the augmenting effect of PG E2 on the heat response of nociceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:day
12
pubmed:volume
162
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
75-7
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Augmenting effects of cyclic AMP on the heat response of canine testicular polymodal receptors.
pubmed:affiliation
Department of Neural Regulation, Nagoya University, Japan.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't