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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-4-4
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pubmed:abstractText |
We investigated the role of interleukin-1 in the induction of a Ca(2+)-independent nitric oxide (NO) synthase by bacterial endotoxin in vivo. In anaesthetized rats, pretreatment with interleukin-1 receptor antagonist (interleukin-1ra; 16 mg kg-1 i.v., followed by an infusion of 2.4 mg kg-1 h-1) ameliorated the delayed hypotension and tachycardia in response to endotoxin (2 mg kg-1 i.v.). Endotoxaemia for 3 h induced a Ca(2+)-independent NO synthase activity in the lung and reduced the contractions to noradrenaline in the thoracic aorta ex vivo. Treatment with interleukin-1ra attenuated both the induction of NO synthase in the lung (by 46 +/- 5%) and the endotoxin-induced hyporeactivity to noradrenaline in the aorta. Thus, endogenous interleukin-1 contributes to the induction of NO synthase in response to endotoxin in vivo.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2999
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
250
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
157-60
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:7509750-Amino Acid Oxidoreductases,
pubmed-meshheading:7509750-Animals,
pubmed-meshheading:7509750-Aorta, Thoracic,
pubmed-meshheading:7509750-Blood Pressure,
pubmed-meshheading:7509750-Endotoxins,
pubmed-meshheading:7509750-Enzyme Induction,
pubmed-meshheading:7509750-Escherichia coli,
pubmed-meshheading:7509750-Heart Rate,
pubmed-meshheading:7509750-Interleukin 1 Receptor Antagonist Protein,
pubmed-meshheading:7509750-Interleukin-1,
pubmed-meshheading:7509750-Lung,
pubmed-meshheading:7509750-Male,
pubmed-meshheading:7509750-Muscle, Smooth, Vascular,
pubmed-meshheading:7509750-Muscle Contraction,
pubmed-meshheading:7509750-Nitric Oxide Synthase,
pubmed-meshheading:7509750-Norepinephrine,
pubmed-meshheading:7509750-Rats,
pubmed-meshheading:7509750-Rats, Wistar,
pubmed-meshheading:7509750-Recombinant Proteins,
pubmed-meshheading:7509750-Sialoglycoproteins
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pubmed:year |
1993
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pubmed:articleTitle |
Interleukin-1 contributes to the induction of nitric oxide synthase by endotoxin in vivo.
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pubmed:affiliation |
William Harvey Research Institute, St. Bartholomew's Hospital Medical College, London, UK.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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