Linked Life Data

7509485

Source:http://linkedlifedata.com/resource/pubmed/id/7509485

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-3-29
pubmed:abstractText
Bone scans, serum tissue-specific polypeptide antigen (TPS), prostate specific antigen (PSA), and neuron-specific enolase (NSE) were assessed in a total of 80 hormonally treated prostate cancer patients. Thirty-nine patients were free of osseous lesions; in 8 subjects, 3 or fewer scintigraphic hot spots were found; in 29 patients, more than 3 bone lesions were recorded. In 3 patients, a partial contribution of endocrine cell cancer structures was found, while in one patient, a homogeneous small cell carcinoma was detected at autopsy. Measurement of the serum PSA test showed a clear-cut rise from stage D0 subjects to stage D2 patients, with a small number of bone lesions (> or = 3). However, a relative decrease in the mean PSA level was measured with further progression in a number of hot spots in bone (> 3). Androgen threshold that is critical for the induction of the PSA (and PAP) expression seems to differ markedly in various cell subpopulations that arise during adenocarcinoma dedifferentiation. This fact explains not only the rise in serum PSA in the majority of progressive and previously castrated subjects after an initial period of hormonal responsiveness, but also a relative decline of androgen-dependent PSA expression with further tumor progression. Localized disease was accompanied with normal or just slightly elevated TPS concentration. In metastatic tumors, serum TPS values revealed a steady increase with the progression in bone. These data seem to reflect not only an increase in tumor proliferation rate with progressively transformed genome, but also the rise in the number of proliferating cells. The presence of nonepithelial transformed tumor structures, such as small cell cancer within a bulk of adenocarcinoma, reduces or normalizes numerical serotests values of both TPS and PSA even during tumor progression. The extent of such decline depends upon the bulk of the endocrine component. The assessment of the above parameters, especially when associated with elevated plasma NSE concentrations, may help in distinguishing an advanced adenocarcinoma with and without elements of malignant neuroendocrine structures. The proposed approach, modified by applying corresponding organ-specific markers, may be checked for its possible general use in staging protocols of various heterogeneous tumors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0270-4137
pubmed:author
pubmed:issnType
Print
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
143-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:7509485-Adenocarcinoma, pubmed-meshheading:7509485-Antigens, Neoplasm, pubmed-meshheading:7509485-Bone Neoplasms, pubmed-meshheading:7509485-Carcinoid Tumor, pubmed-meshheading:7509485-Carcinoma, Small Cell, pubmed-meshheading:7509485-Chromogranin A, pubmed-meshheading:7509485-Chromogranins, pubmed-meshheading:7509485-Humans, pubmed-meshheading:7509485-Immunohistochemistry, pubmed-meshheading:7509485-Liver Neoplasms, pubmed-meshheading:7509485-Lung Neoplasms, pubmed-meshheading:7509485-Male, pubmed-meshheading:7509485-Middle Aged, pubmed-meshheading:7509485-Neoplasm Staging, pubmed-meshheading:7509485-Neoplasms, Multiple Primary, pubmed-meshheading:7509485-Peptides, pubmed-meshheading:7509485-Phosphopyruvate Hydratase, pubmed-meshheading:7509485-Prostate-Specific Antigen, pubmed-meshheading:7509485-Prostatic Neoplasms, pubmed-meshheading:7509485-Testosterone, pubmed-meshheading:7509485-Tissue Polypeptide Antigen, pubmed-meshheading:7509485-Tumor Markers, Biological
pubmed:year
1994
pubmed:articleTitle
A more objective staging of advanced prostate cancer--routine recognition of malignant endocrine structures: the assessment of serum TPS, PSA, and NSE values.
pubmed:affiliation
Clinic of Nuclear Medicine and Oncology, University Hospital Sestre Milosrdnice, Zagreb, Croatia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't