Linked Life Data

7509271

Source:http://linkedlifedata.com/resource/pubmed/id/7509271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-3-25
pubmed:abstractText
Following a baseline night recording, 8 narcoleptic subjects and 8 sex- and age-matched controls were maintained on a 90 min sleep/wake schedule for 48-72 h. Each cycle consisted of 60 min of enforced wakefulness out of bed, followed by a 30 min "nap" period in which subjects were asked to try and fall asleep. Upon completion of the 90 min sleep/wake protocol, subjects were permitted to sleep ad libitum for 24 h. All sleep periods were monitored polygraphically; in addition, tympanic temperature and subjective sleepiness were recorded during the 90 min sleep/wake schedule. Narcoleptics and controls differed dramatically in their sleep patterns during the 90 min sleep/wake schedule. On average, narcoleptics obtained 2 more hours per day of total sleep time (TST) than did the controls, with REM sleep comprising nearly 2/3 of the incremental sleep time. The two groups did not differ with respect to the amount of slow wave sleep (stage 3 + 4; SWS). The sleep latency rhythms observed in control subjects were markedly diminished in narcoleptics; narcoleptic subjects remained objectively sleepy (i.e., had low sleep latencies) even at times corresponding to maximum alertness in the control subjects. Rhythms in subjective sleepiness and core temperature were, however, robust in both groups. Although TST in narcoleptics exceeded that of controls during the 90 min sleep/wake schedule, narcoleptics did not obtain more sleep than controls during the baseline or recovery periods. These findings suggest that the homeostatic process of sleep regulation is intact in narcoleptics. Moreover, it appears that the circadian clock itself is functioning normally in narcoleptics. An attenuated clock effector mechanism responsible for promoting alertness may, however, explain excessive daytime sleepiness in narcoleptics.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
24-35
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Circadian rhythms in narcolepsy: studies on a 90 minute day.
pubmed:affiliation
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94304.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't