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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5150
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pubmed:dateCreated |
1994-3-21
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pubmed:abstractText |
The T cell antigen receptor (TCR) initiates signals by interacting with cytoplasmic protein tyrosine kinases (PTKs) through a 17-residue sequence motif [called the antigen recognition activation motif (ARAM)] that is contained in the TCR zeta and CD3 chains. TCR stimulation induces the tyrosine phosphorylation of several cellular substrates, including the ARAMs. Lck kinase activity is required for phosphorylation of two conserved tyrosine residues in an ARAM. This phosphorylation leads to the recruitment of a second cytoplasmic PTK, ZAP-70, through both of the ZAP-70 Src homology 2 domains and its phosphorylation. Thus, TCR signal transduction is initiated by the sequential interaction of two PTKs with TCR ARAMs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphocyte Specific Protein...,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/Protein-Tyrosine Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Tyrosine,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP-70 Protein-Tyrosine Kinase,
http://linkedlifedata.com/resource/pubmed/chemical/ZAP70 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/antigen T cell receptor, zeta chain
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0036-8075
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
263
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1136-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:7509083-Amino Acid Sequence,
pubmed-meshheading:7509083-Animals,
pubmed-meshheading:7509083-Antigens, CD8,
pubmed-meshheading:7509083-Cell Line,
pubmed-meshheading:7509083-Cytoplasm,
pubmed-meshheading:7509083-Haplorhini,
pubmed-meshheading:7509083-Humans,
pubmed-meshheading:7509083-Lymphocyte Specific Protein Tyrosine Kinase p56(lck),
pubmed-meshheading:7509083-Membrane Proteins,
pubmed-meshheading:7509083-Molecular Sequence Data,
pubmed-meshheading:7509083-Mutation,
pubmed-meshheading:7509083-Phosphorylation,
pubmed-meshheading:7509083-Phosphotyrosine,
pubmed-meshheading:7509083-Protein-Tyrosine Kinases,
pubmed-meshheading:7509083-Receptors, Antigen, T-Cell,
pubmed-meshheading:7509083-Signal Transduction,
pubmed-meshheading:7509083-Tumor Cells, Cultured,
pubmed-meshheading:7509083-Tyrosine,
pubmed-meshheading:7509083-ZAP-70 Protein-Tyrosine Kinase
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pubmed:year |
1994
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pubmed:articleTitle |
Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases.
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pubmed:affiliation |
Howard Hughes Medical Institute, University of California, San Francisco 94143.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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