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pubmed-article:7509040pubmed:abstractTextThe three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.lld:pubmed
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pubmed-article:7509040pubmed:articleTitleInsight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.lld:pubmed
pubmed-article:7509040pubmed:affiliationRoche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.lld:pubmed
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