rdf:type |
|
lifeskim:mentions |
umls-concept:C0023688,
umls-concept:C0079866,
umls-concept:C0115305,
umls-concept:C0233820,
umls-concept:C0242275,
umls-concept:C0444626,
umls-concept:C1514562,
umls-concept:C1704675,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
|
pubmed:issue |
6463
|
pubmed:dateCreated |
1994-3-24
|
pubmed:abstractText |
The three-dimensional structure of the ligand-binding region of human E-selectin has been determined at 2.0 A resolution. The structure reveals limited contact between the two domains and a coordination of Ca2+ not predicted from other C-type lectins. Structure/function analysis indicates a defined region and specific amino-acid side chains that may be involved in ligand binding. These features of the E-selectin/ligand interaction have important implications for understanding the recruitment of leukocytes to sites of inflammation.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
|
pubmed:issn |
0028-0836
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
10
|
pubmed:volume |
367
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
532-8
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:7509040-Amino Acid Sequence,
pubmed-meshheading:7509040-Amino Acids,
pubmed-meshheading:7509040-Animals,
pubmed-meshheading:7509040-Antigens, CD15,
pubmed-meshheading:7509040-CHO Cells,
pubmed-meshheading:7509040-Carrier Proteins,
pubmed-meshheading:7509040-Cell Adhesion,
pubmed-meshheading:7509040-Cell Adhesion Molecules,
pubmed-meshheading:7509040-Cricetinae,
pubmed-meshheading:7509040-Crystallography, X-Ray,
pubmed-meshheading:7509040-E-Selectin,
pubmed-meshheading:7509040-Epidermal Growth Factor,
pubmed-meshheading:7509040-Humans,
pubmed-meshheading:7509040-Lectins,
pubmed-meshheading:7509040-Ligands,
pubmed-meshheading:7509040-Mannose-Binding Lectins,
pubmed-meshheading:7509040-Models, Molecular,
pubmed-meshheading:7509040-Molecular Sequence Data,
pubmed-meshheading:7509040-Mutagenesis,
pubmed-meshheading:7509040-Neutrophils,
pubmed-meshheading:7509040-Rats,
pubmed-meshheading:7509040-Structure-Activity Relationship
|
pubmed:year |
1994
|
pubmed:articleTitle |
Insight into E-selectin/ligand interaction from the crystal structure and mutagenesis of the lec/EGF domains.
|
pubmed:affiliation |
Roche Research Center, Hoffmann-La Roche Inc., Nutley, New Jersey 07110.
|
pubmed:publicationType |
Journal Article
|