Linked Life Data

7508108

Source:http://linkedlifedata.com/resource/pubmed/id/7508108

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
1994-3-4
pubmed:abstractText
High-performance liquid chromatography of FK506, a macrolide immunosuppressant, was performed on a reversed-phase column. The peak was broad with the column kept at room temperature, which was accounted for by slow interconversion between the two forms of FK506. With the use of a heated column, a sharp peak was observed because of the rapid interconversion at high temperature. When the column was cooled to 0 degree C, two sharp peaks were observed because essentially no interconversion occurred at 0 degree C during elution. Analysis of the chromatograms obtained at various eluant flow rates indicated that the conversion of the two forms follows first-order kinetics, and the apparent activation energies for the conversions were calculated. The interconvertibility between the two molecular forms may be related to the immunosuppressive activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0724-8741
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1785-9
pubmed:dateRevised
2000-12-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Kinetic analysis of molecular interconversion of immunosuppressant FK506 by high-performance liquid chromatography.
pubmed:affiliation
Department of Clinical Pathology, Kitasato University School of Medicine, Kanagawa, Japan.
pubmed:publicationType
Journal Article