|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
1994-3-9
|
|
pubmed:abstractText |
We compared the molecular phenotypes of central nervous system tumors arising in four different lines of transgenic mice (TGM) carrying the Simian virus 40 large T antigen driven by different promoters or enhancers. Two of the four lines developed primitive neuroectodermal tumors (PNETs) in the brain stem or pineal gland. A third TGM line developed retinoblastomas (a PNET-like tumor of the retina) as well as PNETs in the mesencephalon, while the fourth TGM developed retinoblastomas and adrenal pheochromocytomas.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0023-6837
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
70
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
114-24
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:7508007-Adrenal Gland Neoplasms,
pubmed-meshheading:7508007-Animals,
pubmed-meshheading:7508007-Antigens, Polyomavirus Transforming,
pubmed-meshheading:7508007-Blotting, Western,
pubmed-meshheading:7508007-Central Nervous System Neoplasms,
pubmed-meshheading:7508007-Disease Models, Animal,
pubmed-meshheading:7508007-Eye Neoplasms,
pubmed-meshheading:7508007-Glial Fibrillary Acidic Protein,
pubmed-meshheading:7508007-Immunohistochemistry,
pubmed-meshheading:7508007-Mice,
pubmed-meshheading:7508007-Mice, Transgenic,
pubmed-meshheading:7508007-Microscopy, Electron,
pubmed-meshheading:7508007-Myelin Basic Proteins,
pubmed-meshheading:7508007-Neuroectodermal Tumors, Primitive,
pubmed-meshheading:7508007-Neurofilament Proteins,
pubmed-meshheading:7508007-Phenotype,
pubmed-meshheading:7508007-Pheochromocytoma,
pubmed-meshheading:7508007-Promoter Regions, Genetic,
pubmed-meshheading:7508007-Retinoblastoma,
pubmed-meshheading:7508007-Synaptophysin,
pubmed-meshheading:7508007-Tumor Cells, Cultured
|
|
pubmed:year |
1994
|
|
pubmed:articleTitle |
Molecular phenotype of simian virus 40 large T antigen-induced primitive neuroectodermal tumors in four different lines of transgenic mice.
|
|
pubmed:affiliation |
Department of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, Philadelphia.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, U.S. Gov't, P.H.S.
|
