Linked Life Data

7507788

Source:http://linkedlifedata.com/resource/pubmed/id/7507788

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-3-4
pubmed:abstractText
It is established that amyloid P (AP) component and complement proteins are associated with amyloid beta (A beta)-protein deposits in the cerebral cortex of Alzheimer's disease (AD) subjects. Here, we used immunocytochemical methods to examine the association of these acute-phase proteins with the characteristic diffuse plaques of cerebellum in AD. We observed AP and complement C3d, C1q, C5 and C4bp immunoreactivities in most A beta-protein-reactive plaques of the cerebellum. Further, a1-antichymotrypsin immunoreactivity was apparent in at least 60% of all the cerebellar diffuse plaques examined. Cerebellar tissue bearing the A beta-protein deposits also often exhibited marked angiopathy in the pial vessels. We suggest that diffuse plaques of the cerebellum also acquire components of the chronic inflammatory response evident in neocortical plaques.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
631
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
151-5
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Amyloid P component and other acute-phase proteins associated with cerebellar A beta-deposits in Alzheimer's disease.
pubmed:affiliation
Department of Neurology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't