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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-18
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pubmed:abstractText |
We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1431144,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1542792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1542793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1600345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1651569,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1705666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1705667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1750501,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1846762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-1928299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2153035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2158239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2162790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2184372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2219269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2293902,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2391587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2459779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2462353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2466335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2561910,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2643161,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2822087,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2823875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2827173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2845275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-2991298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3029867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3122325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3141299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3321434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3341448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3486418,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3753996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3877078,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-3953772,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-549492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507301-7129405
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
51-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7507301-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:7507301-Adult,
pubmed-meshheading:7507301-Aged,
pubmed-meshheading:7507301-Aged, 80 and over,
pubmed-meshheading:7507301-Blood Vessels,
pubmed-meshheading:7507301-Cell Adhesion,
pubmed-meshheading:7507301-Cell Adhesion Molecules,
pubmed-meshheading:7507301-E-Selectin,
pubmed-meshheading:7507301-Humans,
pubmed-meshheading:7507301-Immunohistochemistry,
pubmed-meshheading:7507301-In Situ Hybridization,
pubmed-meshheading:7507301-Sarcoma, Kaposi,
pubmed-meshheading:7507301-Thrombomodulin,
pubmed-meshheading:7507301-Thromboplastin
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pubmed:year |
1994
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pubmed:articleTitle |
Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor.
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pubmed:affiliation |
Department of Medicine, Pathology and Anatomy, University of Heidelberg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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