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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1994-2-18
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pubmed:abstractText |
CD40 is a transmembrane protein that belongs to a superfamily of proteins related to nerve growth factor receptor. CD40 is expressed on B cells and some B cell malignancies. It appears to be involved in B cell proliferation and the prevention of apoptosis in germinal center cells, which is accompanied by expression of bcl-2. Its expression is up-regulated by the EBV protein latent membrane protein-1 and cytokines interleukin-4 and interferon-gamma. The expression of CD40 in 37 cases of Hodgkin's disease and 23 cases of non-Hodgkin's lymphoma (11 T cell lymphomas and 12 B cell lymphomas) was examined by paraffin section immunohistochemistry using the BB-20 monoclonal antibody. In 26 of 37 cases of Hodgkin's disease the Reed-Sternberg cells showed strong membrane or cytoplasmic expression of CD40. Only 3 of 23 non-Hodgkin's lymphomas showed any expression of CD40 and then only weakly. There was no correlation between expression of bcl-2 or latent membrane protein-1 with CD40 expression. These results show that there is probable hyperexpression of CD40 in Hodgkin's disease and suggest that dysregulation of CD40 expression may play a role in the pathogenesis of Hodgkin's disease.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1281209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1310894,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1321789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1371884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1374165,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1648447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1653571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1655907,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1656757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1671232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1702555,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1706378,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1868875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-1951632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2157887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2463309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2475341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2476318,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2477655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2538681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2594086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2787713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2893097,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2982918,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-2998589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-3113255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-3257976,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-3487090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-3492534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-5947336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/7507299-7534045
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
144
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:7507299-Antigens, CD,
pubmed-meshheading:7507299-Antigens, CD40,
pubmed-meshheading:7507299-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:7507299-Antigens, Viral,
pubmed-meshheading:7507299-Hodgkin Disease,
pubmed-meshheading:7507299-Humans,
pubmed-meshheading:7507299-Immunohistochemistry,
pubmed-meshheading:7507299-Lymphoid Tissue,
pubmed-meshheading:7507299-Lymphoma, Non-Hodgkin,
pubmed-meshheading:7507299-Reed-Sternberg Cells,
pubmed-meshheading:7507299-Reference Values,
pubmed-meshheading:7507299-Staining and Labeling,
pubmed-meshheading:7507299-Viral Matrix Proteins
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pubmed:year |
1994
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pubmed:articleTitle |
CD40 expression in Hodgkin's disease.
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pubmed:affiliation |
Department of Pathology, University of Edinburgh, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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